Obstructive sleep apnoea (OSA) is a severe debilitating disorder characterized by repetitive closure of upper airway during sleep and is common in adult population. OSA shows detrimental effects on health, neuropsychological development, quality-of-life, and economic potential and now it is recognized as a public health problem. Recently, American Academy of Sleep Medicine has recommended oral appliances for OSA. Hence, the therapeutic interventions that are directed at the site of airway obstruction in the maxillofacial region are within the scope of dentistry. Treatment of OSA can improve vitality, social and daytime functioning, family life and mental health of a person and hence the quality-of-life. Obesity, craniofacial abnormalities such as micrognathia and retrognathia, genetic predisposition, alcohol, smoking, and sedatives may also predispose to OSA. Treatment modalities for OSA are behaviour modification, diet and medication, CPAP devices, surgical (maxillo-mandibular advancement surgery), and oral appliances.