Coronary catheterization is a minimally invasive procedure to access the coronary circulation and blood filled chambers of the heart using a catheter to recognize occlusion, stenosis and thrombosis. This procedure is commonly performed through the femoral artery, which may induce possible complications like bleeding or hematoma.  These complications led to restricting of patient movement, so the patient has to lie in bed in a supine position for at least 6 hours after angiography. This is an experimental case control study, conducted to evaluate the effect of early mobilization on vascular complications. A sample of 300 adult patients was selected by a random sample technique. They were randomly allocated for 100 patients   in the experimental group and 200 patients in the control group.  The study was conducted from March/2017- March/ 2019 at Ahmed Gasim Cardiac Surgery and Renal Transplantation Hospital in Khartoum State, Sudan. The experimental group was mobilized early at 4 hours and the control group was placed on routine bed rest of 6 hours post sheath removal. Both groups received usual care. A structured questionnaire and checklist were used to collected data. Data was analyzed by using Statistical Packages for Social Sciences (SPSS). The result revealed that the majority of population did not develop bleeding after mobilization,   (97.0%) in the cases and (99.0%) in the controls. While in the control (1%) had hematoma. This study concluded that early mobilization did not increase vascular complications and further studies should be done to decrease bedrest post diagnostic coronary angiography to 3hours or less.