Functional dyspepsia (FD) is the commonest condition approached by a gastroenterologist, with a prevalence of 12% among Indians, resulting reasonable socioeconomic burden. Patients with chronic dyspeptic symptoms for past 3 months prior to consultation, with the onset, at least 6 months preceding the diagnosis, is confirmed with FD, in the absence of any organic, systemic or metabolic basis, that could explain the ensuing pathology, as per the Rome III criteria. The underlying pathophysiologic mechanism is so complex and varied, which includes the alteration in gastric motility, visceral hypersensitivity, altered gastric accommodation, genetic susceptibility, dietary factors, psychosocial factors, and also the infestation by Helicobacter pylori. For these ample ranges of mechanisms, a single drug or approach, seldom provides the results as expected, as per studies. H pylori has to be eradicated if traced out in a person with FD, as per the currently accepted protocol. In this study, Mahatiktakam Kwatham tablet was tried in those included with FD, who were also positive for H pylori with the Rapid Urease Test for a period of 30 days. Post test was done with Stool antigen test (HPSA) after 60 days of the therapy. Aim: To evaluate the role of Mahatiktakam Kwatham tablet in H Pylori positive Functional Dyspepsia Method: Open label uncontrolled study with sample size of 25 Result: There were significant changes in the symptoms of FD on assessment with the Gastrointestinal Symptom Rating Scale (GSRS). There was statistically significant result on H pylori as well, after the intervention as many of the subjects turned negative, for H Pylori. Many of the ingredients are having Raktaprasadana, Rasayana as well as Krimihara properties, which is ideal in managing organisms like H pylori in the gut.