The growth pattern of Monodactylus sabae and Cynoglossus senegalensis in Epe Lagoon Lagos State was investigated. One hundred (100) samples of each species were collected from fishermen catches at the landing site. They were transported to the Department of Zoology Laboratory of Olabisi Onabanjo University for identification, sexing morphometric measurement. The results showed that 56.0% and 58.0 % of the M.sabae and C.senegalensis were female respectively while 44.0% and 42.0% were male respectively.. The length-weight relationship of M.sabae showed a strong regression coefficient (r = 0.944) (p<0.05) for the combined sex, (r =0.903) (p<0.05) for female and (r=0.986) (p<.05) for male with b-value of 2.5, 3.1 and 2.8 respectively. The C.senegalensis also showed a regression coefficient of r=0.970; p<0.05 for the combined sex, r=0.953; p<0.05 for the female and r= 0.979; p<0.05 for the male with b-value of 3.4, 3.1 and 3.6 respectively. M.sabae showed an isometric growth pattern both in male and female. The condition factor in M.sabae are 1.93 and 1.95 for male and female respectively while that of C.senegalensis is 1.95 for both sexes. Positive allometric was observed in both species except the male M.sabae that showed negative allometric growth pattern. From the results of this study, the growth pattern of the two species indicated a good healthy environment.