Introduction: Nootropics, popularly referred to as smart drugs, smart nutrients, cognitive enhancers, brain enhancers and memory enhancers are a class of drugs that improve impaired human cognitive abilities. Mucuna pruriens, belonging to family Fabaceae, has been used in traditional Ayurvedic medicine for various ailments. Present study was undertaken to evaluate the cognitive enhancer activity of acute and chronic administration of Mucuna pruriens in Y maze. Methods: The study was conducted on 30 male Swiss albino mice. Animals were divided into five groups (n = 6 /group): control group (normal saline, p.o.), standard group (Piracetam, 30mg/kg, i.p.) andthree doses of Mucuna pruriens(100, 200, 400 mg/kg, p.o.) for 14 days treatment. Assessment of Spontaneous Alteration Behaviour and total number of entries in different arms using the Y- maze acts as a validated model for measuring learning and memory activity. Results: MPE has shown dose dependent increase SAB on day 7 & day 14. Among the groups which received different doses of MPE, the maximum % alteration rate is seen at dose of 400mg/kg. There is decrease in number of entries from day 7 to day 14 in all the test drugs groups. Highest decrease is seen with MPE in a dose of 400mg/kg which is almost similar to decrease in standard group (Piracetam). Conclusions: This study demonstrated the cognitive enhancer activity (memory, learning etc.) of Mucuna pruriens in Swiss albino mice. The cognitive enhancer activity of Mucuna pruriens was comparable to that of standard drug, piracetam.