The exploratory Ethno medicinal study was undertaken to document how different disease is conceptualized and Diagnosed by traditional healer of purushottampur block of North West Ganjam of Odisha and to record the medicinal plants used in the prevention and treatment of different diseases, their mode of preparation and administration. Out of 50 plants, 36 families and 48 genera identified as being used for treatment of approximately 70 ailments or therapeutic agents. The most cited family Caesalpiniaceae and Lamiaceae are the dominant family followed by Euphobiaceae, Mimosaceae, Solanaceae, Apocyanaceae, Combretaceae, Cucurbitaceae, Liliaceae, Myrtaceae and Rutaceae simultaneously each with two species. The other 18 Families contributed with one species. Out of 70 documented information the plants mostly used for skin diseases, cold and cough, Fever, diarrhea. In the study area the information about usages of medicinal plants ranges from 0.25 to 1.5 with an average value of 0.6. The fidelity levels of different plants were ranged from 7.69% to 100%. Plants (40%) were primary source of medicine, followed by herbs (34%). C. citrates (UV of 1.5) and C. Roseus, L. aspera, R. serpentine (UV of 1.33) at the most frequently and popularly used medicinal plant species in the study area.