Currently, papaya production in South Florida is significantly limited as a result of the papaya ring spot virus. Successful resistance in other countries evidences the potential of GM technology to impact the US domestic papaya economy. In assessing the viability of this solution, we examine the economic benefit in scenarios of GM papaya adoption with varying adoption rates and production areas using an economic surplus method. Estimated total economic surplus generated within the first five years of adoption ranged from USD 13.20 million to USD 37.47 million, with the majority of benefit being received by small-scale producers.