Aim: Study to evaluate the clinical Profile, atypical presentation, the drugs in its treatment and to follow up the cases with atypical presentation of children patient with Kala-azar. Methodology: Patients were studied on the basis of history, examination, investigation and diagnosis. Atypical cases were screened and followed up at 1 wk, 3 months and 6 months. Results:  Data was analyzed by MS Office software. Conclusions:  Kala-azar, in most cases still presents with typical clinical features but cases with atypical presentation is also very common and 10% patients with kala-azar were atypical presentation.